What is unique among the senses in its pathway does not include the thalamus?

The dorsal thalamus, usually simply referred to as the thalamus is a subdivision of a brain area called the diencephalon, which also includes the eptithalamus, the ventral thalamus and the subthalamic thalamus.

What is unique among the senses in its pathway does not include the thalamus?

Vertical section of a human brain. showing the medulla, pons, cerebellum, hypothalamus, thalamus, midbrain. Image Copyright: Designua / Shutterstock

The thalamus relays sensory impulses from receptors in various parts of the body to the cerebral cortex. A sensory impulse travels from the body surface towards the thalamus, which receives it as a sensation. This sensation is then passed onto the cerebral cortex for interpretation as touch, pain or temperature.

The prevailing opinion among experts is that the thalamus serves as a kind of “gate,” filtering which information from various channels is allowed to be relayed by it for processing. Detailed research has shown that specific thalamic neurons can modulate informational transfer by employing specific discharge modes.

Furthermore, the thalamus is crucial for perception, with 98% of all sensory input being relayed by it. The only sensory information that is not relayed by the thalamus into the cerebral cortex is information related to smell (olfaction).

2-Minute Neuroscience: The ThalamusPlay

Thalamic nuclei

The thalamus is made up of three distinct groups of cells or nuclei and these include the following:

  • Sensory relay nuclei - These include the ventral posterior nucleus and the lateral and medial geniculate body. These nuclei relay primary sensations, by passing specific sensory information to the corresponding cortical area. For example, the lateral geniculate body receives information from the optic tract, and then outputs that information to the primary visual cortex.
  • Association nuclei - These receive input from specific areas of the cerebral cortex, which is then projected back to the cerebral cortex to somewhat generalized association areas, where they regulate activity.
  • Non-specific nuclei - These include the intralaminar and midline thalamic nuclei, which both receive input from the cerebral cortex and project information diffusely through it. Most of these nuclei interconnect brain activity between different areas of the brain and play a role in general functions such as alerting.

Aside from olfaction, in all sensory processing, a sensory signal is received by a thalamic nucleus and then directed to the relevant cortical area.

The involvement of thalamic nuclei in sensory systems

In the visual system, the thalamus receives input from the retina, which is relayed to the brain via the optic nerve. Signals are sent to the lateral geniculate nucleus of the thalamus which then forwards them onto the primary visual cortex (area V1) in the occipital lobe. The thalamus not only relays the information but also processes it, as each of the primary sensory relay areas receives information back from the cerebral cortex (called back projections).

On the other hand, the medial geniculate nuclei relay auditory information between the inferior colliculus of the midbrain and the primary auditory cortex. The thalamus is also important for touch - the ventral posterior nuclei relay information regarding touch and perception of bodily position to the primary somatosensory cortex in the cerebral cortex.

In addition, the thalamic nuclei are strongly and reciprocally linked with the cerebral cortex. These form the thalamo-cortico-thalamic circuits which are thought to regulate consciousness and the thalamus plays a significant role in arousal, wakefulness and alertness. Damage to the thalamus is associated with a significant risk of coma.

Your thalamus is your body’s information relay station. All information from your body’s senses (except smell) must be processed through your thalamus before being sent to your brain’s cerebral cortex for interpretation. Your thalamus also plays a role in sleep, wakefulness, consciousness, learning and memory.

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Overview

What is unique among the senses in its pathway does not include the thalamus?
The thalamus is complex part of your brain that's known as the relay station of all incoming motor (movement) and sensory information from your body to your brain.

What is the thalamus?

Your thalamus is an egg-shaped structure in the middle of your brain. It’s known as a relay station of all incoming motor (movement) and sensory information — hearing, taste, sight and touch (but not smell) — from your body to your brain. Like a relay or train station, all information must first pass through your thalamus before being routed or directed to its destination in your brain’s cerebral cortex (the outermost layer of your brain) for further processing and interpretation.

Function

What does the thalamus do?

Your thalamus has many functions, including:

  • Relaying sensory information. Taking in information, in the form of nerve signals, from all of your senses (taste, touch, hearing, seeing), except smell, into your brain. Each sensory function has a thalamic nucleus that receives, processes and transmits the information to its related area within your cerebral cortex.
  • Relaying motor (movement) information. Similar to sensory information, motor pathways all pass through your thalamus.
  • Prioritizing attention. Your thalamus helps decide what to focus on among the vast amount of information that it receives.
  • Role in consciousness. Your thalamus plays a role in keeping you awake and alert.
  • Role in thinking (cognition) and memory. Your thalamus is connected with structures of your limbic system, which is involved in processing and regulating emotions, formation and storage of memories, sexual arousal and learning.

Your thalamus also contributes to perception and plays a role in sleep and wakefulness.

How does your thalamus work?

Sensory impulses (“information”) travel through nerve fibers from your body through brain structures to your thalamus. Specialized areas of your thalamus, called nuclei, are each responsible for processing different sensory or motor impulses received from your body and then sending the selected information through nerve fibers to the related area of your cerebral cortex for interpretation.

This chart names some of the best known nuclei, their function and to what area of your cerebral cortex the information is ultimately sent.

NucleusSuspected function/roleCommunicates with what section of your cerebral cortexAnterior nucleusMemory, emotions, behavior regulationConnected to the hypothalamus; projects to the cingulate gyrusDorsomedial nucleusEmotional behavior and memory; attention, organization, planning and higher cognitive thinkingProjects to the prefrontal cortex and limbic systemVentral posterolateral nucleusRelay sensory information (pain, temperature and touch)Projects to the somatosensory cortexVentral posteromedial nucleusRelay sensory information from the faceProjects to the somatosensory cortexVentral anterior nucleusRelay motor information about movement/tremorProject to the substantia nigra, premotor cortex, reticular formulation and corpus striatumVentrolateral nucleusRelay motor informationProject to the substantia nigra, premotor cortex, reticular formulation and corpus striatumLateral posterior nucleusCognitive, determine prominent visual stimuliProjects to the visual cortexPulvinar nucleusProcess visual informationProjects to the visual cortexMedial geniculate nucleusProcess auditory informationPrimary auditory cortexLateral geniculate nucleusProcess visual informationVisual cortexReticular nucleusMakes up the outer covering of the thalamus; influences the activity of other nuclei within the thalamusDoesn’t project to the cerebral cortex

Anatomy

Where is the thalamus located?

Your thalamus lies above your brainstem in the middle of your brain. Although it may look like a single structure, you actually have two, side-by-side thalami, one in each hemisphere (side) of your brain. Being located in this central area — like the central hub on a bike wheel — allows nerve fibers connections (like the bike wheel’s spokes) to reach all areas of your cerebral cortex (the outer layer of your brain).

Technically, your thalamus is part of an area of your brain called the diencephalon, which includes your hypothalamus, subthalamus and epithalamus.

Conditions and Disorders

What happens if my thalamus is damaged?

Your thalamus is a central relay station for receiving incoming sensory and motor information. Your thalamus then sends this information to other parts of your brain. So, damage to your thalamus can affect many functions.

Symptoms of damage to your thalamus include:

  • Memory loss (amnesia).
  • Lack of interest or enthusiasm (apathy).
  • Loss of ability to understand language or speak (aphasia).
  • Trouble with attention, loss of alertness.
  • Trouble processing sensory information.
  • Impaired movement.
  • Sleepiness.
  • Chronic pain.

Damage to your thalamus can result in:

  • Unconsciousness and even coma.
  • Sleep disorders, such as insomnia and fatal familial insomnia (inability to sleep, leading to death).
  • Thalamic aphasia (jumbled words, meaningless speech).
  • Movement disorders, including tremors.
  • Pain syndromes.
  • Vision problems, including vision loss or light sensitivity.
  • Thalamic pain syndrome (tingling or burning pain).

The main causes of damage to your thalamus include:

  • Stroke in your thalamus.
  • Tumors in your thalamus.

What conditions affect the thalamus?

Certain conditions that are affected by or damage your thalamus include:

  • Fatal familial insomnia. Fatal familial insomnia is a hereditary prion (a type of protein) disease that attacks a particular chromosome. People who are affected develop worsening insomnia that’s joined by panic attacks, paranoia, phobias, hallucinations and a complete inability to sleep. This is followed by rapid weight loss, dementia and inability to speak until death.
  • Creutzfeldt-Jacob disease and Fabry disease. These diseases share a feature that helps diagnose them called the pulvinar sign. A change in density at the back (posterior) of your thalamus appears in the shape of hockey sticks on an MRI scan.
  • Korsakoff syndrome. Caused by alcohol, this syndrome can damage a certain structure in your brain, the mammillothalamic fasiculus, which extends into your thalamus.

Care

Is the thalamus a target for any treatment?

The ventral intermediate nucleus of your thalamus is a target for deep brain stimulation for people with Parkinson’s disease that hasn’t been successfully treated with medications.

A note from Cleveland Clinic

Your thalamus serves as the main relay station for your brain. All motor and sensory signals (except smell) pass through this structure in the center of your brain. Your thalamus is arranged in regions, called nuclei, that each possesses specialization for dealing with that particular information. For example, information coming through your eye travels to your retina, and then onto your optic nerve. It then travels to the lateral geniculate nucleus of your thalamus, which processes the information and sends it to your primary visual cortex for interpretation. The signals are then passed onto your cerebral cortex for interpretation. Your thalamus also plays a role in regulating sleep and wakefulness, and is involved with consciousness.

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Last reviewed by a Cleveland Clinic medical professional on 03/30/2022.

References

  • Guy-Evans O. Thalamus anatomy, function, & disorders. (https://www.simplypsychology.org/thalamus.html) Simply Psychology. 2021, June 09. Accessed 3/30/2022.
  • Sheridan N, Tadi P. Neuroanatomy, Thalamic Nuclei. (https://www.ncbi.nlm.nih.gov/books/NBK549908/) [Updated 2021 Jul 31]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Accessed 3/30/2022.
  • Torrico TJ, Munakomi S. Neuroanatomy, Thalamus. (https://www.ncbi.nlm.nih.gov/books/NBK542184/) [Updated 2021 Jul 31]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Accessed 3/30/2022.

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What is unique among the senses in its pathway does not include the thalamus?

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