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Need multiple seats for your university or lab? Get a quote False Positive Results A false positive result for blood on the reagent strip can occur when oxidizing contaminants, such as hypochlorite (bleach), remain in collection bottles after cleaning. Contamination of the urine with provodine-iodine, a strong oxidizing agent, used in surgical procedures can result in a false positive reaction. Microbial peroxide found in association with urinary tract infections may also cause false-positive results. Capoten® (Captopril) can cause decreased reactivity. The muscle tissue form of hemoglobin, myoglobin is a well-known cause of false-positive reactions on the blood portion of the reagent strip. When tissue hemoglobin is present, the urine specimen has a clear red appearance. Patients suffering from muscle-wasting disorders or muscular destruction due to trauma, prolonged coma, or convulsions or individuals engaging in extensive exertion may have myoglobin in their urine. Specific tests for myoglobin, such as immunodiffusion techniques or protein electrophoresis, are needed to confirm the presence of this substance in a urine specimen. Levels of ascorbic acid normally found in urine do not interfere with this test. Continuing Education Credits
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Additional InformationLevel of Instruction: Basic Intended Audience: Medical laboratory science and medical laboratory technician students, clinical laboratory personnel, and other medical personnel who perform urine dipstick testing at the point-of-care. Author Information: Leah Westover, MPH, MLS(ASCP) is the Director of Sales and Marketing for MediaLab, Inc. Previously, she was the Director of Education and Outreach as well as the Medical Laboratory Science Program Director at St. Christopher’s Hospital for Children in Philadelphia, Pennsylvania. Leah holds a Masters in Public Health from Thomas Jefferson University. Reviewer Information: Alexandru Casapu, MBA, MLS(ASCP)CM, PBTCM has over 20 years of experience as a medical laboratory scientist, section supervisor, and laboratory manager. He is the former Director of Clinical Laboratory Technology Program at Georgia Piedmont Technical College. He is currently a Program Director at MediaLab, Inc. Alexandru holds BS degrees in Biology and Medical Technology from Clark Atlanta University and a MBA from the University of Georgia. Which of the following factors will not interfere with the reaction for leukocytes on the reagent strip quizlet?Which of the following factors will not interfere with the reagent strip test for leukocytes? c: nitrite; Nitrite is produced by bacteria, and WBCs are found when there is a bacterial infection. If nitrite interfered with the reaction then the dipstick would be worthless when testing patients with UTIs.
What can cause errors in reagent strip testing?Interferences: If excess urine is left on the reagent strip, a phenomenon known as runover may occur. The urine from one reagent area carries reagent onto the pH test area and changes the result erroneously.
Which of the following factors will cause a false positive reaction for leukocyte esterase?Doxycycline, gentamicin and some cephalosporins reduce the reactivity of leukocyte esterase and produce false negative results. Conversely, imipenem, meropenem, and clavulanic acid can cause false positive leukocyte esterase reactions.
Which of the following can cause a false positive blood on the reagent strip?A false-positive result for blood on the urine reagent strip can occur if the collection container or reagent strip is contaminated with oxidizing agents, such as hypochlorite (bleach) or if the specimen is contaminated with povidone-iodine, a strong oxidizing agent used in surgical procedures.
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Which of the following will not interfere with the reagent strip test for leukocytes?
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