TK is a 48 year-old male patient known to the pharmacy. His chronic medical conditions include hypertension, high cholesterol, depression and gout. He has been taking valsartan, hydrochlorothiazide, pravastatin, amlodipine, and allopurinol chronically and started sertraline about 3 months ago. About a month ago, his physician increased the doses of sertraline, valsartan and allopurinol to better manage his chronic conditions. Today, TK presents
to the pharmacy and informs you that he is having difficulty with sexual performance, and has very little desire to be intimate with his wife. This is a new problem for him, which he finds quite upsetting. Which medication may be causing TK's problem? Show
A Acne Virilization in a woman is the most common reaction associated with anabolic steroids, especially when higher doses are used. Acne occurs frequently in all age groups and both sexes. Nausea, vomiting, diarrhea, fluid and electrolyte imbalances (the same as for the androgens, discussed previously), testicular atrophy, jaundice, anorexia, and muscle cramps may also be seen. Fluid retention, not deficiency, is a common side effectof anabolic steroid use. Sedation and hypotension are not adverse reactions to this hormone. "One transdermal patch is applied to my back, upper arm, or abdomen to dry, clean skin, and the other to my groin." The nurse needs to clarify the statement that the client made regarding applying the transdermal patch to the groin. The client should not apply the patch to the groin. The client needs to rotate sites, so there is 7 days before another patch is paced on the area of skin. The thigh was not mentioned, which may be used as a site. The other statements are correct. Common adverse effects of the drug include acne, headache, bitter taste or mouth irritation, hair loss, and increase in libido. The client may weigh self once or twice a week, and should report if there is an increase in weight, which reflects fluid retention. Keeping appointments for follow-up is essential because hypercalcemia can occur leading to renal calculi, polyuria, nausea and vomiting, and abdominal pain. "If I eat a fatty meal I will need to take two pills instead of one, so the drug will take effect faster." The nurse needs to clarify the statement that the client made regarding doubling the dosage after eating a fatty meal. Fatty foods delay the action of the drug. Taking two tablets could lead to excessive dosing and the adverse effect, priapism. The other statements are correct. If the client develops priapism for longer than 4 hours, medical attention is needed to prevent permanent damage to the penis. A rare event, nonarteritic ischemic optic neuropathy (NAION) is an adverse effect of the drug, which leads to the obstruction of circulation to the optic nerve resulting in irreversible loss of vision in one or both eyes. Also, a rare adverse effect, permanent loss of hearing with ringing in the ears, or tinnitus may occur. A client taking sildenafil should not take nitrates because it can cause a serious drop in blood pressure, dizziness, syncope, heart attack, or stroke. Recommended textbook solutions
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Which drug will the nurse anticipate being prescribed for a patient with mild prostatic enlargement?Finasteride (Proscar) is used alone or in combination with another medication (doxazosin [Cardura]) to treat benign prostatic hypertrophy (BPH, enlargement of the prostate gland).
Which action of finasteride helps in the treatment of benign prostatic hypertrophy?Finasteride blocks the action of an enzyme called 5-alpha-reductase. This enzyme changes testosterone to another hormone that causes the prostate to grow or hair loss in males. It will increase testosterone levels in the body, which decreases prostate size and increases hair growth on the scalp.
Which category of drugs is contraindicated with the concurrent use of the phosphodiesterase inhibitor sildenafil?Hypersensitivity is an absolute contraindication to all phosphodiesterase inhibitors. Nitrites are contraindicated to use alongside PDE-5 inhibitors: sildenafil, tadalafil, vardenafil, and avanafil, as they may result in severe hypotension.
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