What causes myasthenia gravis (MG)? Show In all these diseases, an army of immune cells that would normally attack bacteria and disease-causing "germs" mistakenly attacks cells and/or proteins that play an essential role in the body. In most cases of MG, the immune system targets the acetylcholine receptor — a protein on muscle cells that is required for muscle innervation and eventually contraction (see illustration to the right). At the normal neuromuscular junction, a nerve cell causes a muscle cell to contract by releasing the chemical acetylcholine (ACh). ACh attaches to the ACh receptor — a pore or "channel" in the surface of the muscle cell — twisting it open and allowing an inward flux of electrical current that triggers muscle contraction. These contractions enable someone to move a hand, to dial the telephone, to walk through a door, or to complete any other voluntary movement. About 85% of people with MG have antibodies against the ACh receptor (AChR) in their blood. The antibodies (Y-shaped protein that immune cells, called B cells, use to attack bacteria and viruses) target and destroy many of the AChRs on muscle. Consequently, the muscle’s response to repeated nerve signals declines with time, and the muscles become weak and eventually disappear. Scientists do not know what triggers most autoimmune reactions, but they have a few theories. One possibility is that certain viral or bacterial proteins mimic "self-proteins" in the body (such as the AChR), stimulating the immune system to unwittingly attack the self-protein. There's also evidence that an immune system gland called the thymus plays a role in MG (see illustration below). Located in the chest just below the throat, the thymus is essential to the development of the immune system. From fetal life through childhood, the gland trains immune cells called T cells to distinguish self from non-self. What is the genetic susceptibility in MG?Although MG and other autoimmune diseases are not hereditary, genetic susceptibility does appear to play a role. It seems likely that genetic factors also contribute to the pathogenesis of MG. Certain human leukocyte antigen (HLA) types, cell-surface proteins that are responsible for the regulation of the immune system, have been associated with myasthenia, including HLA-B8, DRw3, and DQw2.1 MuSK antibody-positive myasthenia is associated with haplotypes (clusters of genes inherited together) DR14 and DQ5.2 Most studies suggest that if people have a relative with an autoimmune disease, their risk of getting an autoimmune disease is increased — the closer the relative, the higher the risk. Even for identical twins, however, that risk is relatively small. Most studies suggest that when one twin has an autoimmune disease, the other has less than a 50% chance of getting the same disease. Also, people who already have one autoimmune disease have a greater risk of developing another one. It is estimated that 5% to 10% of people with MG have another autoimmune disease that appeared before or after the onset of MG. The most common of these are autoimmune thyroid disease, rheumatoid arthritis, and systemic lupus erythematosus (a disease that affects multiple organs). References
What receptors are destroyed in myasthenia gravis?In myasthenia gravis, antibodies (immune proteins produced by the body's immune system) block, alter, or destroy the receptors for acetylcholine at the neuromuscular junction, which prevents the muscle from contracting.
How does antibodies cause myasthenia gravis?Myasthenia gravis occurs when the immune system makes antibodies that destroy the ACh receptor (AChR), a docking site for the nerve chemical acetylcholine (ACh). Some treatments block acetylcholinesterase (AChE), an enzyme that breaks down ACh, while others target the immune system.
Is myasthenia gravis driven by antibodies?Myasthenia gravis (MG) is an autoimmune disease characterized by muscle weakness and fatiguability of skeletal muscles. It is an antibody-mediated disease, caused by autoantibodies targeting neuromuscular junction proteins.
What is the mechanism of action for myasthenia gravis?Myasthenia gravis (MG) is a relatively rare autoimmune disorder in which antibodies form against nicotinic acetylcholine (ACh) postsynaptic receptors at the neuromuscular junction (NMJ) of the skeletal muscles, causing muscle weakness and rapid muscle fatigue.
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Myasthenia gravis is due to receptors being blocked and destroyed by antibodies
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