Booster COVID-19 vaccination for recommended groups who have already completed their primary course with any COVID-19 vaccine type Show
Frequently asked questions for vaccinators and health professionals First Booster InformationSecond Booster InformationAdditional resources
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This page undergoes regular review and was last comprehensively reviewed on November 1, 2022. Some sections may reflect more recent updates. Dosing SchedulesThe four COVID-19 vaccines available for use in the U.S. follow various dosing schedules. All four vaccines have been demonstrated to be highly effective against severe outcomes related to COVID-19 in clinical trials and postauthorization observational studies. However, given concerns about waning immunity and the emergence of novel variants, there is interest in understanding the potential role of alternative dosing strategies for these vaccines to augment or prolong their protective effect, including (but not limited to) administration of additional doses of each vaccine, schedules containing different products (“mix and match”) and modified dosing intervals. Although individuals may receive the second dose in the primary series at extended intervals, shorter intervals are still recommended for moderately to severely immunocompromised individuals, adults aged 65 and older and others who need rapid protection. The very small risk of myocarditis, especially for males aged 12-39 years, may be further reduced with an extended interval between primary doses. Additional Primary Series DosesImmunocompromised PopulationsFDA has authorized and CDC recommends an additional dose of COVID-19 mRNA vaccine as part of the primary series for certain immunocompromised populations. Key primary studies that have evaluated the effect of additional doses of COVID-19 vaccines as part of a primary series in immunocompromised populations include: mRNA vaccines
Viral vector vaccines
Immunocompetent PopulationsThere is no current recommendation to offer a third dose of COVID-19 vaccine as part of the primary series to immunocompetent adults. There are limited data on the effect of a third dose used in this context. However, the emergency use authorization of Pfizer-BioNTech vaccine in children 6 months-4 years has a third dose included in the primary series. The third dose was added to the primary series after immunobridging success criteria were not met for this age group with only two primary series vaccine doses. mRNA vaccines
Viral vector vaccines
Booster DosesIn the U.S., CDC recommends everyone ages 5 years and older receive one updated bivalent mRNA COVID-19 vaccine booster dose after completing their mRNA, viral vector or recombinant subunit primary COVID-19 vaccination series. Children who are 5 years old are only recommended to receive the Pfizer-BioNTech bivalent booster; children 6 years old and older can receive either Pfizer-BioNTech or Moderna bivalent booster. All bivalent boosters should be received at least 2 months after completion after the primary series, or at least 2 months after the last monovalent booster dose. Bivalent mRNA vaccines contain both a vaccine antigen against the ancestral strain of SARS-CoV-2 as well as an antigen against BA.4/BA.5 Omicron subvariants. These bivalent vaccines have the same total antigen amount as adult monovalent vaccines (i.e., in the U.S., Moderna bivalent vaccine contains 25 mcg of spike protein from ancestral SARS-CoV-2 and 25 mcg of spike protein from Omicron (BA.4/BA.5) SARS-CoV-2, whereas primary series doses each contain 50mcg of spike protein from ancestral SARS-CoV-2; Pfizer bivalent vaccine contains 15 mcg of spike protein from each antigen, whereas primary series doses each contain 30mcg of spike protein from the ancestral strain only). Bivalent boosters should be administered without regard to the number of previous monovalent booster doses received. CDC suggests that where possible, booster vaccines to be received should “match” the vaccines received in the primary series (e.g., individuals receiving Moderna primary series vaccines should, where possible, receive a Moderna bivalent booster). Individuals should only receive one bivalent booster dose. CDC recommends all booster doses be bivalent mRNA vaccines (regardless of the vaccine type received for primary series). An analysis of safety data gathered through the v-safe surveillance system found that booster doses were safe overall and associated with fewer reactogenicity events than second doses of mRNA vaccine (Hause, February 2022). However, individuals aged 18 years and older who are unable to receive a bivalent mRNA booster, or who refuse to receive a bivalent mRNA booster, may receive a Novavax booster starting 6 months after primary series completion. EvidenceBooster doses augment immune responses (quantitatively or qualitatively) against SARS-CoV-2 (and relevant variants). Data for augmented immune responses following booster doses come from several studies. In a substudy of the Phase 1 clinical trial of the Pfizer-BioNTech COVID-19 vaccine, 23 participants received a booster dose of the vaccine at approximately 8 months after completion of the primary series. One month after the booster dose, neutralizing antibody titers against both wildtype virus and the Beta (B.1.351) and Delta (B.1.617.2) variants had increased to levels higher than at 1 month after the primary series (Falsey, September 2021). In another study of 97 Israeli healthcare workers aged ≥60 years who received a third dose of the Pfizer-BioNTech COVID-19 vaccine approximately 6-7 months after their primary series, the additional vaccine dose significantly increased anti-spike IgG antibody titers measured 10-19 days after vaccination (Eliakim-Raz, November 2021). The two largest studies were multicenter studies that compared the safety and immunogenicity of a variety of different booster vaccines, including heterologous doses. In an interim analysis of a multicenter trial conducted at 10 sites in the U.S., the investigators reported immune responses following heterologous and homologous booster doses among >400 participants who had previously been vaccinated with either two doses of an mRNA COVID-19 vaccine or one dose of the Johnson & Johnson/Janssen COVID-19 vaccine (at least 12 weeks earlier). In this study, a booster dose with any product augmented antibody concentrations, but heterologous boosts (“mixed” regimens) elicited a more robust response than homologous boosts (“matched” regimens) (Atmar, January 2022). In another large study conducted in the U.K., the investigators reported immune responses following heterologous and homologous boosters among >2800 participants who had previously received either two doses of the Oxford-AstraZeneca or Pfizer-BioNTech COVID-19 vaccine (at least 10-12 weeks earlier). Participants were randomized to receive boosts with the Oxford-AstraZeneca, Pfizer-BioNTech, Moderna or Johnson & Johnson/Janssen COVID-19 vaccines, as well as the Novavax COVID-19 vaccine, the CureVac mRNA COVID-19 vaccine and an inactivated vaccine. All the booster vaccines augmented immune responses following a Pfizer-BioNTech COVID-19 vaccine series, with the two currently authorized mRNA COVID-19 vaccines demonstrating the greatest effect (Munro, December 2021). Limitations The durability of these augmented immune responses is unknown. In a longitudinal study of immune responses to SARS-CoV-2 following mRNA COVID-19 vaccination (mostly the Pfizer-BioNTech COVID-19 vaccine), the investigators separately analyzed the kinetics of the immune response in individuals with and without prior SARS-CoV-2 infection. For those with prior infection, the primary vaccine series may already be considered a “booster.” In this group, antibody, memory B cell and T cell responses were augmented by vaccination but had declined nearly back to baseline by 6 months (Goel, October 2021). Booster doses lead to increased vaccine effectiveness against COVID-19. Multiple studies have evaluated the clinical effectiveness of a COVID-19 vaccine booster dose. These are mostly observational cohort studies during time periods when either Delta or Omicron were the predominant circulating variants. Together, the data indicate that a booster dose of an mRNA COVID-19 vaccine (i.e., a third dose given several months after a two-dose primary series) provides a significant protective effect against symptomatic COVID-19 (Bar-On, September 2021; Saciuk, November 2021; Patalon, November 2021; Bar-On, December 2021), COVID-19 hospitalization and death compared with two doses of vaccine (Barda, October 2021; Arbel, December 2021; Andrews, January 2022). Preliminary evidence suggests this may also be the case for NVX-CoV2373 when used as a booster after ChAdOx1 or BNT162b2 primary series (Munro, December 2021). The emergence of the Omicron variant and its capacity for immune escape also motivated a number of studies to evaluate the benefits of booster doses. Booster doses of mRNA COVID-19 and the Johnson & Johnson/Janssen COVID-19 vaccines appear to restore in vitro neutralization titers (Nemet, December 2021; Garcia-Beltran, December 2021; Pajon, January 2022; Lyke, January 2022 – preprint, not peer-reviewed) as well as clinical effectiveness (Andrews, December 2021 – preprint, not peer-reviewed; Thompson, January 2022; Johnson, January 2022; Accorsi, January 2022; Gray, December 2021 – preprint, not peer-reviewed; Hui Xuan Tan, February 2022; Ferdinands, February 2022). As an example, in a non-peer-reviewed analysis of SARS-CoV-2 infections in the U.K. following the emergence of the Omicron variant, the authors found that two doses of the Pfizer-BioNTech COVID-19 vaccine demonstrated a vaccine effectiveness against symptomatic COVID-19 (presumed due to Omicron) of 88.0% (95% CI, 65.9-95.8%) 2-9 weeks after dose 2, 48.5% (95% CI, 24.3-65.0%) at 10-14 weeks post dose 2 and 34-37% from 15 weeks post dose 2; 2 weeks after a booster dose with the Pfizer COVID-19 vaccine, vaccine effectiveness had increased to 75.5% (95% CI, 56.1-86.3%) (Andrews, December 2021 – preprint, not peer-reviewed). Limitations The durability of this improvement in vaccine effectiveness is poorly characterized. In an analysis of urgent care encounters, emergent department visits and hospitalizations due to COVID-19 in the VISION Network in the U.S., investigators found waning effectiveness of third (booster) doses of mRNA COVID-19 vaccines against all three outcomes after 2 months, during both the Delta and Omicron waves. Notably, booster dose effectiveness waned more significantly against urgent care and emergency department encounters, but showed more durability against hospitalization, remaining greater than 75% for up to 4 months after vaccination during both time periods (Ferdinands, February 2022). Bivalent booster doses likely provide additional protection against Omicron subvariants of SARS-CoV-2. Preliminary safety and efficacy information presented at a Sept. 1, 2022 ACIP meeting suggest that the inclusion of a second SARS-CoV-2 variant antigen in mRNA vaccines broadens the overall antibody response to SARS-CoV-2. In presentations to ACIP, safety data about bivalent vaccines from approximately 1,400 individuals was presented. The information presented concerned bivalent vaccines, all of which included an antigen for the SARS-CoV-2 ancestral strain; some bivalent vaccines also included antigen for the BA.1 Omicron subvariant and others included antigen for BA.4/BA.5 Omicron subvariants. Overall, Omicron-specific bivalent booster vaccines resulted in higher anti-Omicron antibody and higher antibody titers for other SARS-CoV-2 variants. Modeling work presented at this meeting suggested that broad uptake of these updated bivalent vaccines in the early fall of 2022 could prevent a substantial number of hospitalizations. Mixed Productssubunit and viral vector COVID-19 vaccines. Interim CDC guidance addresses clinical considerations related to heterologous booster doses, including patient benefit-risk considerations when selecting which booster dose to receive. EvidencePrimary series There have been few studies evaluating a mixed product primary series with the vaccines currently available in the U.S. The largest such study, the Com-COV2 trial, was conducted in the U.K. and compared the safety and immunogenicity of two doses of the Pfizer-BioNTech and Oxford-AstraZeneca vaccines with heterologous schedules containing one dose of either followed by one dose of either the Moderna or Novavax COVID-19 vaccine (Stuart, December 2021). The safety and immunogenicity of a vaccine series containing two doses of the Pfizer-BioNTech vaccine were similar to a vaccine series containing one dose of Pfizer-BioNTech followed by one dose of Moderna. Antibody and cellular response were slightly higher in the mixed schedule group, which may be attributable to the higher antigen content in the Moderna vaccine rather than any benefit of a mixed schedule per se. The Com-COV2 trial and other studies outside the U.S. have also evaluated mixed schedules containing one dose of an mRNA vaccine and one dose of the Oxford-AstraZeneca vaccine (which is based on a similar technology to the Johnson & Johnson/Janssen COVID-19 vaccine), though the time between the first and second dose of vaccine in these studies has been variable. Most of these studies have concluded that a two-dose schedule that includes both vaccines, in either order, generates a robust antibody and cellular response, compared with a single dose of either vaccine. Furthermore, in the studies where a heterologous and homologous (i.e., containing two doses of the same vaccine product) schedule were directly compared, the safety profile and immune responses with both schedules appeared to be similar (Borobia, June 2021; Shaw, May 2021; Liu, August 2021; Ostadgavahi, May 2021; Hillus, November 2021; Schmidt, September 2021; Tenbusch, July 2021; Dimeglio, August 2021). In some studies, a heterologous schedule containing one Oxford-AstraZeneca and one mRNA COVID-19 vaccine dose elicited a more robust cellular response and higher neutralizing antibody titers against SARS-CoV-2 variants than a homologous schedule containing two doses of the Oxford-AstraZeneca vaccine (Barros-Martins, July 2021; Kaku, February 2022). Boosters Some studies suggest that heterologous boosters may be superior to homologous boosters. Per CDC guidance, mRNA COVID-19 boosters are preferred over the Johnson & Johnson/Janssen COVID-19 vaccine. Data to support this recommendation come from studies on immunogenicity (Atmar, January 2022; Munro, December 2021; Sablerolles, January 2022) and clinical effectiveness (Mayr, February 2022; Hui Xuan Tan, February 2022). Timing/IntervalsThe interval between doses of two-dose COVID-19 vaccines may impact their immunogenicity and clinical effectiveness. However, to date there are limited data for this strategy; therefore, alternative schedules are not currently recommended. Key primary studies that have evaluated the effect of alternate COVID-19 vaccine schedules are summarized below. mRNA vaccine intervalThere is accumulating evidence that a longer interval between the two doses of mRNA COVID-19 vaccines may confer improved immunogenicity and potentially even clinical effectiveness. Studies in the U.K. and Canada have demonstrated that a longer time period (ranging from 6-16 weeks depending on the study) between the two doses of both the Pfizer-BioNTech and Moderna COVID-19 vaccines is associated with increased antibody and cellular responses (Parry, August 2021; Grunau, November 2021; Grunau, December 2021; Payne, November 2021). A separate analysis in the U.K. of 750 adults aged 50-79 years confirmed these findings and further demonstrated that an interval of >45 days between dose one and two of the Pfizer-BioNTech COVID-19 vaccine was associated with improved vaccine effectiveness (over a follow-up period that preceded emergence of the Delta variant) against SARS-CoV-2 infection (Amirthalingam, December 2021). Viral vector vaccine intervalIn an exploratory analysis of a Phase 3 randomized controlled trial of the Oxford-AstraZeneca COVID-19 vaccine, investigators evaluated the impact of variable timing of the second dose of vaccine. In this analysis, vaccine efficacy against primary symptomatic COVID-19 (starting 14 days after the second dose) was higher with longer dose intervals. Vaccine efficacy was 55.1% (95% CI, 33.0-69.9) when the interval between the two doses was less than 6 weeks and 81.3% (60.3-91.2) when the interval was more than 12 weeks (Voysey, February 2021). Coadministration (with non-COVID-19 vaccines)Per CDC recommendations, COVID-19 vaccines can be administered without regard to timing of other vaccines. Of note, the effect of coadministration or closely spaced administration of COVID-19 and non-COVID-19 vaccines on immunogenicity and reactogenicity has not yet been well characterized. Individuals receiving an orthopoxvirus vaccine (JYNNEOS or ACAM2000) may consider waiting 4 weeks before receiving a COVID-19 vaccine due to a risk of myocarditis/pericarditis associated with orthopoxvirus vaccines. If an orthopoxvirus vaccine is being administered in the context of prophylaxis, administration should not be delayed because of recent receipt of a COVID-19 vaccine. ResourcesHow many seconds are counted when assessing a child's respirations?Count the respirations for 30 seconds and double that number to determine the respiratory rate. Remember that respiratory rates that are too fast or too slow for the child's development prevent adequate oxygenation.
Which of the following is the appropriate area for measuring the head circumference?Head circumference or OFC [occipital frontal circumference] is measured over the most prominent part on the back of the head (occiput) and just above the eyebrows (supraorbital ridges). This can be translated to mean the largest circumference of the head.
What is the only vaccine that is contraindicated in healthy infants under 6 months of age?ACIP recommends that yellow fever vaccine never be given to infants aged <6 months.
Which muscle is the preferred site for injections on infants to 2 years of age?For infants and younger children receiving more than two injections in a single limb, the thigh is the preferred site because of the greater muscle mass.
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