A nurse is caring for a client who is about to begin taking pioglitazone to treat type 2 diabetes

a. thyroid-stimulating hormone (TSH)
b. alanine aminotransferase
c. LDL
d. CBC
e. creatine clearance

b,c
Alanine aminotransferase (ALT) is correct. Pioglitazone can cause liver injury. The nurse should monitor ALT at the start of therapy and then every 3 to 6 months thereafter. The nurse should tell the client to report jaundice, dark-colored urine, or abdominal pain.LDL is correct. Pioglitazone can cause elevations in both high-density lipoproteins, which is a beneficial effect, and LDLs, which is a detrimental effect. The nurse should monitor the client's plasma lipid levels at baseline and periodically throughout drug therapy.